This study assesses the motion of organs in the abdomen during abdominal imaging. About two thirds of cancer patients will have radiation therapy as part of their treatment. Radiation oncologists may use imaging scans to plan radiation treatment. Images are used in radiation treatment planning to develop precise and accurate delivery of radiation to make sure that tumors are in the radiation target field at all times and to make sure that nearby organs at risk are avoided. However, during imaging and radiation treatments, organs in the abdomen, such as the liver, pancreas, bowel, bladder and blood vessels, move during normal breathing. Tumors that are in the abdomen also move with breathing. This study may help researches develop the ability to estimate the motion of both tumor and organs to plan and deliver more precise radiation therapy in patients with cancers located in the abdomen.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT05674851.
PRIMARY OBJECTIVES:
I. To systematically analyze abdominal organ motion (respiratory motion, gastrointestinal (GI) motility motion and inter-fractional motion).
II. To understand the physical mechanisms of abdominal organ motion and the interactions between organs caused by the organ motion.
III. To develop a mathematic model, which will estimate the motion of the organs and tissues in the entire abdomen, if given the information to drive the model, for example, the position of the diaphragm which is known to drive the respiration motion.
IV. To simultaneously estimate 3 dimensional (D) motion from 2D orthogonal magnetic resonance imaging (MRI) images using a motion model.
OUTLINE: This is an observational study. This study involves a retrospective and prospective analysis.
RETROSPECTIVE: Computed tomography (CT) images from patient's medical charts reviewed on study.
PROSPECTIVE: Healthy volunteers undergo a 4D-MRI and/or a 2D-Cinema (Cine) MRI on study.
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationDuke University Medical Center
Principal InvestigatorDeshan Yang
