Study of PYX-201 in Solid Tumors

Inclusion Criteria

• Inclusion 1. Histologically or cytologically confirmed solid tumors including locally advanced/metastatic NSCLC, HR+ and HER2- breast cancer, HR- and HER2-positive breast cancer, TNBC, HNSCC, ovarian cancer, thyroid cancer, pancreatic ductal adenocarcinoma (PDAC), sarcomas, hepatocellular carcinoma (HCC), kidney cancer, cervical cancer and endometrial cancer. 2. Male or non-pregnant, non-lactating female participants age ≥18 years. 3. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 to 1. 4. Participant must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. 5. Life expectancy of >3 months, in the opinion of the Investigator. 6. Corrected QTcF <470 msec. 7. Adequate hematologic function. 8. Adequate hepatic function. 9. Adequate renal function. 10. Adequate coagulation profile. 11. Clinical sites must conduct fresh tumor biopsy or provide participant's archived tumor tissue sample. Exclusion 1. History of another malignancy except for the following: adequately treated local basal cell or squamous cell carcinoma of the skin; in situ cervical carcinoma; adequately treated, noninvasive bladder cancer. 2. Known symptomatic brain metastases. 3. Significant cardiovascular disease within 6 months prior to start of study drug. 4. Evidence of an active systemic bacterial, fungal, or viral infection requiring treatment at the start of study drug. 5. Known active hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). 6. Failure to recover to baseline severity or Grade ≤1 NCI-CTCAE v5.0 from acute non-hematologic toxicity. 7. Participants with NCI-CTCAE v5.0 Grade >1 neuropathy of any etiology. 8. Prior solid organ or bone marrow progenitor cell transplantation. 9. Prior high-dose chemotherapy requiring stem cell rescue. 10. Received systemic anticancer therapy within 28 days or within 5 half-lives (whichever is shorter) prior to the start of study drug. 11. Palliative radiation therapy within 14 days prior to the start of study drug. 12. Previously received extra domain B splice variant of fibronectin (EDB+FN) targeting treatments at any time prior to the start of PYX-201 treatment. 13. History of uncontrolled diabetes mellitus. 14. History of Stevens-Johnson syndrome or toxic epidermal necrolysis. 15. Participants with corneal epithelial disease, with the exception of mild punctate keratopathy 16. Participants with the best-corrected visual acuity in the worst-seeing eye worse than 20/100 (Snellen equivalent).