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Lattice Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

Trial Status: active

This clinical trial studies how well lattice radiation therapy (LRT) works compared to stereotactic body radiation therapy (SBRT) in treating patients with a solid tumor cancer that has spread beyond its original location (metastatic) to soft tissue (such as muscle, fat, or blood vessels). Lattice radiation therapy (LRT) uses radiation to create a certain pattern of high dose radiation alternating with areas of lower dose, very similar to poking holes into a tumor. SBRT is a type of radiation therapy that delivers very precisely targeted high-dose radiation in a very even dosing pattern, without the pattern of alternating high and low dose areas. LRT may be as effective as SBRT in treating patients with solid tumors metastatic to soft tissue. This trial may also help researchers learn how the different radiation therapy techniques (LRT and SBRT) affect how many immune cells are able to attack and kill tumor cells (immune infiltration).