A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Inclusion Criteria

• ≥18 years old
• Histologically or cytologically confirmed advanced or metastatic malignancies as defined in the protocol.
• Part 1: Participants must have experienced disease progression after treatment with, be intolerant to, or be ineligible for, or refused available therapies, including anti-PD-(L)1 or anti-CTLA4 therapy if applicable, that are known to confer clinical benefit. Part 2: depending on cohort, participants may have received or not prior treatment for the malignancy under study.
• ECOG performance status score of 0 or 1.
• Willingness to undergo pre- and on-treatment tumor biopsy (core or excisional). Biopsies are mandatory depending on the cohorts.
• Presence of measurable disease according to RECIST v1.1.

Exclusion Criteria

• Any known additional malignancy that is progressing or requires active treatment, or history of other malignancy within 2 years.
• Not recovered to ≤ Grade 1 or baseline from residual toxicities of prior therapy.
• Has active autoimmune disease requiring systemic immunosuppression with corticosteroids.
• Brain or CNS metastases untreated or that have progressed.
• History of organ transplant, including allogeneic stem cell transplantation.
• History of clinically significant or uncontrolled cardiac disease.
• Active HBV, active HCV, or HIV positive.
• Is on chronic systemic steroids (> 10 mg/day of prednisone or equivalent).
• Chronic or current active infectious disease requiring systemic antibiotics, antifungal, or antiviral treatment
• Participants that have been initiated on or had modifications in anticoagulation therapies within the last 3 months prior to first dose of treatment.
• Significant concurrent, uncontrolled medical condition, eg:
• Cardiovascular: Participants with known vasculitis, aneurisms, and other vascular malformations of clinical significance or history of myocarditis.
• Gastrointestinal: Any bowel obstruction within 60 days prior to C1D1.
• Participants with adequate laboratory values within the protocol defined ranges. Other protocol-defined Inclusion/Exclusion Criteria may apply.