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Vaping THC-containing Liquids vs. Smoked Cannabis to Reduce Systemic Exposure to THC in Patients Who Are Current Users

Trial Status: approved

This phase I trial compares vaping THC containing liquids to smoking cannabis to reduce systemic exposure to THC in patients who are current users of both products. While smoking cannabis remains the most common mode of THC use among adults and youth, alternative modes of delivery, such as Electronic Vaping Products (EVPs), are becoming increasingly popular for the delivery of cannabinoids. Declining cannabis risk perceptions, increasing normalization of cannabis, greater legal access and availability to cannabis, ease of administration, and ability to conceal vaped THC use have likely contributed to increasing prevalence of use throughout the population across all age groups. Comparing vaping THC containing liquids with smoking cannabis can serve as an important benchmark for evaluating the delivery and effects of THC vaping products and, their relative safety.

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