A Study of D3S 001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

Inclusion Criteria

• Inclusion: - Subject must have a histologically or cytologically confirmed metastatic or locally advanced solid tumor which is progressing. - Subject must have documented KRAS p.G12C mutation identified within the last 5 years by a local test on tumor tissue or blood. - Subject must have measurable disease per RECIST v1.1. - Subject must have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. - Subject must have adequate organ and marrow function within the screening period. Exclusion: - Subject has any prior treatment with other treatments without adequate washout periods as defined in the protocol. - Subject has uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, uncontrolled or significant cardiovascular disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirements, substantially increase risk of incurring AEs, or compromise the ability of the subject to give written informed consent. - Subject has unresolved treatment-related toxicities from previous anticancer therapy of NCI CTCAE Grade ≥2 (with exception of vitiligo or alopecia). - Subject has active gastrointestinal disease or other that could interfere significantly with the absorption, distribution, metabolism, or excretion of oral therapy. - Concurrent participation in any clinical research study involving treatment with any investigational drug, radiotherapy, or surgery, except for the nontreatment phases of these studies (e.g., follow-up phase). Other protocol inclusion/exclusion criteria may apply