This clinical trial studies how well a multimodal prehabilitation program works in improving nutrition, physical function, and sleep health in older adult patients with esophageal cancer who are undergoing surgery. Multimodal prehabilitation is defined as a suite of conservative, preventative interventions offered to surgical candidates intended to optimize physical, emotional, and mental well-being before the day of surgery. The prehabilitation program provides recommendations and education to optimize a patient’s well-being prior to surgery in order to improve patient outcomes after surgery. Researchers want to find out if a multimodal prehabilitation program works to improve nutrition, physical function, and sleep health in older adult patients with esophageal cancer who are undergoing surgery.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT06027515.
Locations matching your search criteria
United States
Massachusetts
Boston
Massachusetts General Hospital Cancer CenterStatus: Active
Contact: Hassan Dashti
Phone: 617-726-9132
PRIMARY OBJECTIVE:
I. To test whether a novel surgical multimodal prehabilitation protocol at Massachusetts General Hospital is feasible in at-risk older adult patients who have previously undergone neoadjuvant chemotherapy or radiotherapy and are scheduled for, or a potential candidate for, surgical removal of esophageal cancer.
SECONDARY OBJECTIVE:
I. Examining changes in health-related, cognitive, and patient-reported outcomes, as well as measured metabolic and physical function outcomes in patients enrolled in a multimodal prehabilitation program before esophageal cancer surgery.
OUTLINE:
Patients participate in a personalized prehabilitation program consisting of individualized nutritional recommendations and immunonutrition supplements, sleep education, and a targeted and individualized physical function program for at least 4 weeks leading up to the day of surgery. Patients also receive inspiratory muscle training for the duration of the prehabilitation program. Patients wear an actigraphy device and use a WiFi-enabled scale on study. Patients also undergo blood sample collection throughout the study.
After completion of study intervention, patients are followed up at 6 months.
Trial PhaseNo phase specified
Trial Typesupportive care
Lead OrganizationDana-Farber Harvard Cancer Center
Principal InvestigatorHassan Dashti
