Evaluating the Effects of Total Intravenous Anesthesia, Compared to Balanced Anesthesia, on Intraocular Pressure during Surgery for Gynecologic Cancer

This phase IV trial examines the effects two different anesthesia approaches (total intravenous anesthesia [TIVA] versus balanced anesthesia) have on the pressure within the eyeball (intraocular) during robotic surgery for gynecologic cancers. Patients who are undergoing gynecologic surgeries are often put in a position called the steep Trendelenburg position, in which the patient is angled at around 45 degrees in the head-down position. This positioning has been shown to increase intraocular pressure, which can lead to temporary or even permanent vision changes. Anesthetic drugs such as propofol, fentanyl, rocuronium, isoflurane, lidocaine, and ketamine are used to induce a loss of feeling and/or consciousness to prevent patients from feeling pain. Different anesthetic techniques have been shown to alter intraocular pressure. Anesthesia delivered exclusively via a vein (intravenously) (TIVA) has been shown to have more favorable effects on intraocular pressure as opposed to anesthesia techniques that use both intravenous and inhaled approaches (balanced anesthesia). Currently, all gynecological robotic surgeries use the balanced approach. The use of TIVA during surgery may be effective at protecting patients from changes in intraocular pressure during gynecologic surgery.

Additional locations may be listed on ClinicalTrials.gov for NCT04281017.

Trial PhasePhase IV

Trial Typesupportive care

Lead OrganizationUF Health Cancer Institute - Gainesville

Principal InvestigatorSonia D. Mehta

• Primary IDUF-GYN-001
• Secondary IDsNCI-2023-08818, OCR33027
• ClinicalTrials.gov IDNCT04281017