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Chemotherapy and Radiation with or without Liposomal Irinotecan using Molecular Risk for the Treatment of Children with Rhabdomyosarcoma

Trial Status: active

This phase II trial tests the safety and effectiveness of liposomal irinotecan along with chemotherapy and radiation, using molecular risk to determine treatment, for children with rhabdomyosarcoma. Vincristine is in a class of medications called vinca alkaloids. It works by stopping tumor cells from growing and dividing and may kill them. Dactinomycin is a type of antibiotic that is only used in cancer chemotherapy (antineoplastic antibiotic). It works by damaging the cell’s DNA and may kill tumor cells. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell’s DNA and may kill tumor cells. It may also lower the body’s immune response. Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It blocks a certain enzyme needed for cell division and DNA repair and may kill tumor cells. Liposomal irinotecan is a form of the anticancer drug irinotecan that is contained inside very tiny, fat-like particles. Liposomal irinotecan may have fewer side effects and work better than other forms of the drug. Chemotherapy drugs, such as vinorelbine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Giving chemotherapy with liposomal irinotecan and radiation using molecular risk may be safe, tolerable and/or effective in treating children with rhabdomyosarcoma.