One Fraction Simulation-Free Treatment with CT-Guided Stereotactic Adaptive Radiotherapy for Oligometastatic and Primary Lung Tumors, ONE STOP Trial
This phase II trial tests the effectiveness of one fraction simulation-free stereotactic body radiation therapy, ONE STOP workflow, in treating patients with lung cancer or another cancer that has spread to the lung (oligometastatic). Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors and is a part of routine care for people with lung tumors that can't be removed by surgery. Stereotactic body radiation therapy (SBRT) is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. Although SBRT is standard for some kinds of lung tumors, access to this treatment can be limited for some people. The ONE STOP SBRT workflow delivers radiation therapy into a single dose, or fraction, reducing the amount of time spent for treatment into a single appointment. ONE STOP SBRT workflow may be an effective method of radiation treatment for patients with lung cancer or a cancer that has spread to the lung.