Assessing Benefits and Harms of Cannabis and Cannabinoid Use Among a Cohort of Cancer Patients Treated in Community Oncology Clinics, COSMIC Study

Inclusion Criteria

• * Adults aged 18 years or older with one of the following newly diagnosed cancers: breast cancer, colorectal cancer, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer (e.g., adenocarcinoma, squamous cell carcinoma, large cell carcinoma, adenosquamous cell carcinoma, and not otherwise specified). * Planned treatment with systemic chemotherapy (single or multi-agent, includes targeted therapy) and/or immune checkpoint inhibitor therapy (targeting PD-1, PD-L1 or CTLA-4). If unable to engage participant before treatment starts, enrollment is allowed up to the start of cycle 2 treatment. * Participants must be able to comprehend English or Spanish (for survey completion). * Participant must have a working email address and be willing to complete surveys online. This can be completed at home, in the clinic or other location. * Completion of the confidential Self-reported Screening Survey and receipt of a screening result - eligible for enrollment. * Participant must reside in the United States, officially determined per patient report on Self-reported Screening Survey. * In the treating provider’s opinion, the participant should have a life expectancy of >= 6 months. Participants in hospice are not eligible. SUBSTUDY: * Must be willing to participate in both the main study and the sub-study at the VA010, VA205, NC002, NC042, NC132, NC246 or NC275 site. * Must be receiving treatment at the VA010, VA205, NC002, NC042, NC132, NC246 or NC275 site. * Must be diagnosed with non-small cell lung cancer. * Must be planning to receive paclitaxel as part of their chemotherapy in conjunction with Immune checkpoint inhibitor (ICIs) targeting PD-1, PD-L1 or CTLA-4.

Exclusion Criteria

• * Currently enrolled in an interventional supportive treatment trial to manage cancer symptoms. * Participants with known pregnancy. * Participant received systemic therapy treatment for prior cancer(s) including chemotherapy, immunotherapy, targeted therapy, and hormonal therapy. * Participants enrolled in hospice. SUBSTUDY: * Participants with chronic or ongoing steroid or immunomodulatory agents (i.e., prednisone, dexamethasone, etanercept, infliximab, etc.). The use of glucocorticoids as pre-medications for chemotherapy treatment is allowed. * Participants with a history of HIV, hepatitis B or hepatitis C.