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SW-682 in Advanced Solid Tumors
Trial Status: active
This is a first-in-human (FIH), Phase 1a/1b open-label, multicenter, dose escalation and
dose expansion study of SW-682 in adult participants with metastatic or unresectable
advanced solid tumors with or without Hippo pathway alterations that are refractory to,
or have progressed, during or after appropriate prior systemic anticancer therapy,
including chemotherapy, immunotherapy, radiation therapy or targeted therapy, or for
which no treatment is available, or prior standard of care (SOC) therapy was not
tolerated and for which there is no further SOC treatment available. The study includes a
Part 1 (Phase 1a) dose escalation phase and a Part 2 (Phase 1b) dose expansion to
optimize the dose to be used for further development. All participants will
self-administer SW-682 by mouth in 28-day cycles.
Inclusion Criteria
Histologically confirmed, metastatic, or unresectable solid cancer that has either not responded to or progressed during or after appropriate prior systemic anticancer therapy including chemotherapy, immunotherapy, radiation therapy, or appropriate targeted therapy, or for which there is no treatment available or prior SOC therapy was not tolerated and for which there is no further SOC treatment available
Part 1: must have one of the following:
Mesothelioma with or without NF2 mutations
Advanced solid tumors with NF2 mutations
Advanced solid tumors with other Hippo pathway mutations or fusions (e.g., FAT1, LATS1/2, YAP fusions; WWTR1-CAMTA1 in EHE).
Part 2: must have the tumor histology and oncogenic mutation or genomic aberration specific to each dose expansion cohort defined below:
Cohort 1: Participants with mesothelioma with or without NF2 mutations
Cohort 2: Participants with advanced solid tumors with NF2 mutations
Cohort 3: Participants with advanced solid tumors with other Hippo pathway mutations identified during Part 1 (Phase 1a) dose escalation
Cohort 4: SW-682 with appropriate combination therapy.
In both parts, participants should have known oncogenic mutation identified by Next Generation Sequencing or local assay
Must have archival tumor tissue or agree to a fresh tumor biopsy at screening
Measurable disease per RECIST 1.1
Eastern Cooperative Oncology Group (ECOG) performance status of ≤1
Adequate bone marrow, kidney, hepatic, and coagulation function Key
Exclusion Criteria
Evidence of symptomatic CNS metastases, leptomeningeal carcinomatosis, or untreated spinal cord compression
Clinically significant cardiac disease or abnormal cardiac parameters
Preexistence or inheritance of a familial renal syndrome
Concomitant non-anti-arrhythmic medications that are known to prolong the QTc interval
Concomitant medicines that are known strong/moderate inhibitors or inducers of cytochrome P450 3A4 (CYP3A4) and/or CYP1A2 within 14 days or 5 half-lives before the first dose of study treatment
Concomitant medicines that are known sensitive substrates of CYP3A4, CYP2C19, CYP2D6, CYP1A2, and/or CYP2B6 within 14 days or 5 half-lives before the first dose of study treatment
Concomitant medicines that are known sensitive substrates of PGP, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1, MATE2-K, OCT2
Clinically significant active infection (bacterial, fungal, or viral)
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT06251310.
