A Pilot Study to Assess the Functional Capacity of Esophageal and Lung Cancer Patients Receiving Neoadjuvant Therapy

Inclusion Criteria

• * Patient 18 years of age or older. * Patient with newly diagnosed esophageal and lung cancer undergoing neoadjuvant chemotherapy, radiation therapy, and/or immunotherapy. * Patients who have signed the consent form to participate in the study. * Patients must have been evaluated in the Perioperative Evaluation and Management (POEM) Center or by a staff Anesthesiologist. * All laboratory and diagnostic evaluations required or used to evaluate the patient must be completed. All patients must be approved to undergo anesthesia by the standards of the POEM Center. * No samples belonging to vulnerable populations (children, pregnant women, cognitively impaired adults or prisoners) will be allowed from participation.

Exclusion Criteria

• * Patient is under age 18. * Patient is unwilling to sign consent. * Patient is unable to exercise (bedridden or wheel chair bound). * Patient is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC. * Patient’s condition is deemed unsatisfactory for surgery after the preanesthetic evaluation. * Patient has had a myocardial infarction within three months of the preanesthetic evaluation or presents with new or unstable angina. * Patient has a history of a cerebrovascular accident or transit ischemic attacks within three months of the preanesthetic evaluation. * Patient has a history of a pulmonary embolic event within three months of the preanesthetic evaluation. * Patient is known to have acute or chronic deep vein thrombosis. * Patient is pregnant.