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Mosunetuzumab and Zanubrutinib for the Treatment of Patients with Relapsed or Refractory Marginal Zone Lymphoma

Trial Status: active

This phase II trial tests the safety, side effects and effectiveness of mosunetuzumab and zanubrutinib in treating patients with marginal zone lymphoma that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Zanubrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. Giving mosunetuzumab and zanubrutinib may be safe, tolerable and/or effective in treating patients with relapsed or refractory marginal zone lymphoma.