This clinical trial evaluates whether a prehabilitation intervention can help to reduce inflammation for American Indian (AI) patients with obesity-related solid tumor cancer. Obesity-related inflammation likely drives cancer risk and adverse outcomes, and yet, this is a reversible process. Omega-rich foods, like walnuts, which have a high content of polyunsaturated fatty acids and antioxidants can improve blood lipid profiles, reduce stress, influence inflammatory biomarkers (biological molecule found in blood, other body fluids, or tissues that is a sign of a condition or disease), and reduce tumor growth, offering a natural and tasty way of improving outcomes. Prehabilitation, or prehab, is a health program that helps cancer patients get ready for surgery. It uses things like physical activity and nutrition to help make patients stronger and have a better recovery after surgery. A nutrition and exercise prehabilitation intervention may be effective in reducing inflammation in AI patients with obesity-related solid tumor cancer.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT06644560.
Locations matching your search criteria
United States
Arizona
Tucson
Banner University Medical Center - TucsonStatus: Active
Contact: Jennifer Erdrich
Phone: 520-621-2377
PRIMARY OBJECTIVES:
I. Implement the prehab translational clinical trial for AI patients with obesity-related solid tumor cancer scheduled for surgery.
II. Measure host and tumor-microenvironment (TME) biomarkers using paired serum and tissue samples to compare baseline and post-intervention levels of expression.
EXPLORATORY OBJECTIVE:
I. Assess differential expression of inflammatory genes in the TME using tumor tissue samples to compare baseline and post-intervention levels of expression.
OUTLINE:
Patients participate in a prehabilitation program consisting of consume walnuts daily, attend individualized supervised physical activity training sessions twice a week (BIW) over 1 hour, attend a nutrition session with a nutritionist for 30-60 minutes, and walk daily for 30 minutes for 3 weeks. Patients also receive a pedometer, educational materials, and text reminders on study and undergo blood sample collection at baseline and on study.
Trial PhaseNo phase specified
Trial Typeprevention
Lead OrganizationBanner University Medical Center - Tucson
Principal InvestigatorJennifer Erdrich