This clinical trial evaluates whether a prehabilitation intervention can help to reduce inflammation for American Indian (AI) patients with cancer scheduled for treatment. Inflammation likely drives cancer risk and adverse outcomes, and yet, this is a reversible process. Omega-rich foods, like walnuts, which have a high content of polyunsaturated fatty acids and antioxidants can improve blood lipid profiles, reduce stress, influence inflammatory biomarkers (biological molecule found in blood, other body fluids, or tissues that is a sign of a condition or disease), and reduce tumor growth, offering a natural and tasty way of improving outcomes. Prehabilitation, or prehab, is a health program that helps cancer patients get ready for treatment. It uses things like physical activity and nutrition to help make patients stronger and feel better during treatment. A nutrition and exercise prehabilitation intervention may be effective in reducing inflammation in AI patients with cancer scheduled for treatment.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT06644560.
Locations matching your search criteria
United States
Arizona
Tucson
Banner University Medical Center - TucsonStatus: Active
Contact: Jennifer Erdrich
Phone: 520-621-2377
PRIMARY OBJECTIVES:
I. Implement the prehab translational clinical trial for AI patients with cancer scheduled for treatment.
II. Measure host and tumor-microenvironment (TME) biomarkers using paired serum and tissue samples to compare baseline and post-intervention levels of expression.
EXPLORATORY OBJECTIVE:
I. Assess differential expression of inflammatory genes in the TME using tumor tissue samples to compare baseline and post-intervention levels of expression.
OUTLINE:
Patients participate in a prehabilitation program consisting of consume walnuts daily, attend individualized supervised physical activity training sessions twice a week (BIW) over 1 hour, attend a nutrition session with a nutritionist for 30-60 minutes, and walk daily for 30 minutes for 3 weeks. Patients also receive a pedometer, educational materials, and text reminders on study and undergo blood sample collection at baseline and on study.
Trial PhaseNo phase specified
Trial Typeprevention
Lead OrganizationBanner University Medical Center - Tucson
Principal InvestigatorJennifer Erdrich