Testing Whether Changes in Platelet RNA Enhance the Early Diagnosis of Ovarian Cancer

Inclusion Criteria

• Study Population 1: Women with a Recent Diagnosis of Ovarian Cancer: * Women aged 21 years or older * Diagnosed with any stage or type of ovarian cancer within the last 8 weeks Study Population 2: Control Women without Ovarian Cancer: * Women aged 21 years or older Study Population 3: Women with a Recent Diagnosis of Ovarian Mass: * Women aged 21 years or older * Diagnosed with any type of ovarian mass within the last 8 weeks

Exclusion Criteria

• Study Population 1: Women with a Recent Diagnosis of Ovarian Cancer: * Any other active malignancy * Other diagnosis of any cancer within the last 6 months * Treatment for any cancer within the last 6 months * History of ovarian cancer at any time * Currently receiving chemotherapy for ovarian cancer * Has already undergone complete ovarian mass resection * Unable to provide blood sample Study Population 2: Control Women without Ovarian Cancer: * Any active malignancy or diagnosis of cancer within the last 6 months * Treatment for any cancer within the last 6 months * Hospitalization or surgery (other than minor surgery such as mole removal) within the last 8 weeks * Renal failure (defined as eGFR < 60 mL/min/1.73m² or on dialysis) * Liver failure (defined as having hepatic encephalopathy of any degree, OR moderately severe coagulopathy defined as INR ≥ 1.5, OR known cirrhosis, OR ALT of ≥ 10X ULN, OR total bilirubin of ≥ 3.0 mg/dL, OR diagnosis of liver failure) * Decompensated or end-stage heart failure (defined as ACC/AHA Stage C or Stage D heart failure) * Poorly controlled diabetes mellitus (defined as a HbA1c > 9.0%) * Venous thrombosis, myocardial infarction, or stroke within the last 8 weeks * Currently pregnant or have been pregnant within the last 12 weeks * Any blood product transfusion within the last 8 weeks * Personal history of ovarian cancer at any time * History of bilateral salpingo-oophorectomy * History of oophorectomy * Unable to provide blood sample Study Population 3: Women with a Recent Diagnosis of Ovarian Mass: * Any diagnosis of active malignancy * Any diagnosis of any cancer within the last 6 months * Treatment for any cancer within the last 6 months * History of ovarian cancer at any time * Currently receiving chemotherapy for ovarian cancer * Has already undergone complete ovarian mass resection * Unable to provide blood sample