Specialized Stem Cell Transplant Product (CD34+ Selected Donor Cells) for the Treatment of Low Blood Counts after Donor Stem Cell Transplant
This clinical trial tests how well CD34+ selected donor cells work in treating low blood counts after donor stem cell transplant (poor graft function or graft failure). In many instances, donor stem cell transplant represents the only therapy that offers a cure for underlying disease conditions. Successful transplant depends on engraftment, in which donor blood cells replace the patient's blood cells at normal levels. However, engraftment is not achieved for all patients and poor graft function or graft failure can occur. Poor graft function or graft failure is a serious complication of transplant. The usual treatments for poor graft function or graft failure are rarely successful. New therapies are needed to help treat poor graft function or graft failure. Using CD34+ selected donor cells may be a useful treatment for poor graft function of graft failure. In this trial, donor stem cells are collected and then processed using the CliniMACS® CD34 Reagent System. The CliniMACS® CD34 Reagent System isolates CD34+ cells and separates CD34+ donor cells from donor T-cells. The CD34+ and T-cells are separated so patients can receive only the CD34+ cells and not the T-cells. Patients receiving additional T-cells could increase the chance of another transplant complication, graft versus host disease (GVHD), or other GVHD related complications. CD34+ cells are responsible for creating white blood cells that fight infections, red blood cells that carry oxygen throughout the body, and platelets that prevent bleeding. The infusion of CD34+ cells may help poor graft function or graft failure by creating normal levels of white and red blood cells and reduce or eliminate the need for additional medications to promote the development of blood cells as well as blood and platelet transfusions. Giving CD34+ selected donor cells may be safe and effective in treating patients with poor graft function or graft failure.