Validation of Wearable Sensors to Monitor Tissue Hydration and Stiffness in Patients with Lymphedema

Inclusion Criteria

• * Patients with a diagnosis of unilateral lymphedema that affects the upper extremity (axillary fold, medial side of the upper arm, forearm and/or hand). * Patients previously diagnosed with non-metastatic cancer. * Adults 18 years of age and older. * Ability to understand and willingness to sign an IRB approved written informed consent document.

Exclusion Criteria

• * Patients with history of lymphatic surgery. * Patients with implantable devices (e.g., pacemaker, pacemaker/defibrillator, intrathecal pump, joint replacements, etc.) or any other device deemed unsafe by the clinical expert investigator. * Patients with Body mass index (BMI) larger than 32 (Patients with larger BMI will have super thick skin that stymies the thermal transport of our sensor, thus, reduces the sensor sensitivity.) * Patients with an amputation involving the upper extremity. * Patients with known allergies to adhesives – including silicone adhesives and Tegaderm. * Patients with the following comorbidities: uncontrolled diabetes, congestive heart failure, peripheral vascular disease, scarred upper extremity skin, psoriasis, atopic dermatitis, open wounds/skin breakdown. * NOTE: patients with other diseases impacting the skin barrier, or known active infections such as cellulitis, which will be determined at the discretion of the treating investigator.