Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE Trial)
The purpose of this research study is to see if researchers can detect any remaining bladder cancer using a procedure called a cystourethroscopy with biopsy. Cystourethroscopy with biopsy is a procedure that allows the study doctor to see inside the bladder and take samples along with the analysis of samples of blood, urine and stool. Researchers want to use the results to see if the genetic and molecular features of bladder tumors can help improve the diagnosis and treatment of this disease. Blood and urine samples will be taken to measure small amounts of DNA released from the tumor into the blood and urine. This is known as circulating tumor DNA or “ctDNA” in the blood and cell free DNA or “cfDNA” in the urine. Changes in ctDNA have been associated with whether bladder cancer has responded to previous treatments like tumor resections with a scope or chemotherapy. Researchers would also like to test stool samples to see the microorganisms (bacteria) in the gut. This study wants to see if the bacteria that usually live in the gut can help predict whether there is any disease left or not.