Olverembatinib for the Treatment of Chronic Myeloid Leukemia in Newly Diagnosed Patients in the Chronic Phase

Inclusion Criteria

• Adult patients age ≥ 18 years
• Patients must have a diagnosis of Philadelphia chromosome (Ph)-positive or BCR::ABL1 positive CML in early chronic phase (i.e., time from diagnosis ≤ 12 months)
• Patients who received prior hydroxyurea, 1 to 2 doses of cytarabine, and/or an Food and Drug Administration (FDA) approved tyrosine kinase inhibitor (TKI) for ≤ 30 days are eligible
• Patients with additional chromosomal abnormalities at diagnosis (early disease) and no other criteria for accelerated phase will be eligible for this study
• Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
• Total bilirubin ≤ 1.5 x upper limit of normal (ULN) (unless secondary to Gilbert’s disease, in which case should be ≤ 2.5 x ULN)
• Serum glutamic pyruvic transaminase (SGPT) or serum glutamic oxaloacetic transaminase (SGOT) ≤ 3 x ULN
• Creatinine clearance ≥ 30mL/min calculated using modified Cockcroft-Gault
• Ability to understand and the willingness to sign a written informed consent document
• The effects of olverembatinib on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and 4 months after completion of olverembatinib administration. (Refer to Pregnancy Assessment Policy MD Anderson Institutional Policy # CLN1114). This includes all female patients, between the onset of menses (as early as 8 years of age) and 55 years unless the patient presents with an applicable exclusionary factor which may be one of the following: * Postmenopausal (no menses in greater than or equal to 12 consecutive months) * History of hysterectomy or bilateral salpingo-oophorectomy * Ovarian failure (follicle stimulating hormone and estradiol in menopausal range, who have received whole pelvic radiation therapy) * History of bilateral tubal ligation or another surgical sterilization procedure
• Approved methods of birth control are as follows: Hormonal contraception (i.e. birth control pills, injection, implant, transdermal patch, vaginal ring), intrauterine device (IUD), tubal ligation or hysterectomy, subject/partner post vasectomy, implantable or injectable contraceptives, and condoms plus spermicide. Not engaging in sexual activity for the total duration of the trial and the drug washout period is an acceptable practice; however periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of birth control. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
• Men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and 4 months after completion of olverembatinib administration
• For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
• Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
• Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression
• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
• Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2 or better

Exclusion Criteria

• Patients who have received more than 30 days of prior FDA approved TKI or more than 2 doses of cytarabine
• Had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study
• Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities > grade 1) with the exception of alopecia
• Patients who are receiving any other investigational agents
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to olverembatinib or other agents used in study
• New York Heart Association (NYHA) cardiac class 3-4 heart disease
• Cardiac symptoms: Patients meeting the following criteria are not eligible unless cleared by cardiologist * Uncontrolled angina within 3 months * Diagnosed or suspected congenital long QT syndrome * Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes) * Prolonged corrected QT interval (QTc) interval on pre-entry electrocardiogram (> 460 msec)
• History of significant bleeding disorder unrelated to cancer, including unless cleared by hematologist or hemato-oncologist: * Diagnosed congenital bleeding disorders (e.g., von Willebrand’s disease) * Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies)
• Patients with active, uncontrolled psychiatric disorders including psychosis, major depression, and bipolar disorders
• Patients with cognitive impairment or psychiatric illness/social situations that would limit compliance with study requirements
• Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
• Evidence of other clinically significant uncontrolled condition(s) including, but not limited to: * Uncontrolled and/or active systemic infection (viral, bacterial or fungal) * Chronic hepatitis B virus (HBV) or hepatitis C (HCV) requiring treatment and having detectable virus load. Note: subjects with serologic evidence of prior vaccination to HBV (i.e. hepatitis B surface antigen negative, hepatitis B virus surface antibody [anti-HBs] antibody positive and anti-hepatitis B core antibody negative) or positive hepatitis B virus core antibody (anti-HBc) antibody from intravenous immunoglobulins may participate
• Pregnant women are excluded from this study because olverembatinib is a BCR::ABL1 TKI with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with olverembatinib, breastfeeding should be discontinued if the mother is treated with olverembatinib. These potential risks may also apply to other agents used in this study
• Patients in late chronic phase (i.e., time from diagnosis to treatment > 12 months), accelerated (except as noted) or blast phase are excluded. The definitions of CML phases are as follows: * Early chronic phase: time from diagnosis to therapy ≤ 12 months * Late chronic phase: time from diagnosis to therapy > 12 months * Blastic phase: presence of 30% blasts or more in the peripheral blood or bone marrow * Accelerated phase CML: presence of any of the following features: ** Peripheral or marrow blasts 15% or more ** Peripheral or marrow basophils 20% or more ** Thrombocytopenia < 100 x 10^9/L unrelated to therapy ** Documented extramedullary blastic disease outside liver or spleen