Hyperpolarized Xenon-129 Magnetic Resonance Imaging for Improving Radiation Therapy for Lung Cancer

Inclusion Criteria

• Aged 18-80 years
• Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.)
• Clinical diagnosis of lung cancer made by a board certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease

Exclusion Criteria

• Subject is less than 18 years old or incarcerated
• MRI is contraindicated based on responses to MRI screening questionnaire
• Subject is pregnant or lactating
• Resting oxygen saturation < 90% on supplemental oxygen
• Respiratory illness of bacterial or viral etiology within 30 days of planned treatment
• Subject has history of any known ventricular cardiac arrhythmia
• Subject has history of cardiac arrest within the last year
• Subject has prior history of cancer treatment with radiation therapy to the lung
• Subject has concurrent cancer treatment with agents associated with increased risk of radiation pneumonitis (e.g. immunotherapy, chemotherapy)
• Subject does not fit into 129 Xe vest coil used for MRI
• Subject cannot hold his/her breath for 15 seconds
• Subject deemed unlikely to be able to comply with instructions during imaging
• Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject’s ability to comply with the protocol requirements