The BEACON Trial: Defining the Natural History and Diagnostic Tools for Breast Lymphedema After Treatment for Breast Cancer

Inclusion Criteria

• * Longitudinal Study: ** Eligible participants will be female, ≥ 18 years, newly diagnosed with unilateral, non-metastatic breast cancer who underwent breast-conserving surgery +/- LN removal (SLNB or ALND). Because of the extremely low incidence of BC in children and males, only female participants over the age of 18 will be included. ** Eligible participants must have radiation therapy planned at MGH ** Eligible participants will have no residual cancer in the breast after definitive breast surgery * PILOT Study: Additionally, eligible participants will have completed radiation therapy for breast cancer greater than or equal to 3 months ago

Exclusion Criteria

• * Participants who have bilateral BC will not be eligible due to the need for an unaffected control breast. * Participants will not be eligible if they have been diagnosed and/or treated for BCRL. * Participants will not be eligible if they have metastases that may cause BCRL. Participants with metastatic disease will be excluded. * Participants with implanted cardiac devices and those who are pregnant will be excluded from the SOZO measurement component of the study. * PILOT Study: ** Those who have been diagnosed and/or treated for breast edema or lymphedema of the arm will NOT be excluded. ** Of the 30 patients to be enrolled in the pilot study, 15 will have breast edema and 15 will not.