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Patritumab Deruxtecan for the Treatment of Patients with Newly Diagnosed or Recurrent Brain Metastases

Trial Status: active

This phase II trial investigates whether patritumab deruxtecan can be measured in brain tumor tissue before undergoing brain surgery in patients that have a diagnosis of a brain tumor that is new or has come back after a period of improvement (recurrent), has spread from one part of the body to another (mestatatic), and can be removed surgically (resectable). Patritumab deruxtecan is a monoclonal antibody directed against the human epidermal growth factor receptor HER3 linked to a chemotherapy drug DX 8951. Patritumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of tumor cells, known as HER3 receptors, and delivers DX 8951 to kill them. Giving patritumab deruxtecan before undergoing brain surgery may kill more tumor cells and be able to be detected in brain tissue.