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Immunosensitizing Radiation with Neoadjuvant Chemoimmunotherapy for the Treatment of Patients with Stage II-IIIC Borderline Resectable Non-Small Cell Lung Cancer, The NeoRADjuvant Trial

Trial Status: active

This phase I trial tests the safety, side effects and effectiveness of adding radiation to standard of care chemoimmunotherapy, with nivolumab, carboplatin or cisplatin and paclitaxel or pemetrexed or gemcitabine, for the treatment of patients with stage II-IIIC non small cell lung cancer that may be able to be removed by surgery (borderline resectable). Stereotactic body radiation therapy (SBRT) is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make DNA and may kill cancer cells. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill cancer cells. Giving SBRT with chemoimmunotherapy may be safe and effective in treating patients with borderline resectable stage II-IIIC non small cell lung cancer.