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A Study of Changes to Prostate Procedures

Trial Status: active

This phase III trial studies whether changing care during prostate procedures improves the outcomes of patients following the procedure (post-procedure) compared to standard care. Prostate procedures can include transperineal prostate needle biopsies and prostate gland ablation. A transperineal prostate needle biopsy uses a needle to take tissue samples from the prostate gland through the perineum, which is the area between the scrotum and the anus. While transperineal prostate needle biopsies have fewer complications, patients often experience high rates of post-procedure pain despite being put to sleep with medication (sedation). The change in care for transperineal prostate needle biopsy in this trial includes giving a medication, bupivacaine hydrochloride, to areas near the prostate (locally) to cause a temporary loss of feeling, which may improve post-procedure pain. Prostate gland ablation uses energy to destroy prostate tissue. For this procedure, a flexible plastic tube (foley catheter) is inserted into the bladder to provide continuous urinary drainage, which can lead to the inability to completely empty the bladder with urination (urinary retention). The change in care for prostate gland ablation in this trial includes giving medications such as tamsulosin, oxybutynin, celecoxib, phenazopyridine, ketorolac, and dexamethasone or methylprednisolone before and after the procedure to lower prostate swelling and inflammation as well as burning with urination. This may lower urinary retention post-procedure. Making changes during prostate procedures may improve post-procedure patient outcomes.