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Fitting Non-Invasive Tests in Lynch Syndrome Surveillance: A Prospective Clinical Study
Trial Status: active
This study gathers information about a colorectal cancer screening method called fecal immunochemical test in people with Lynch syndrome.
Inclusion Criteria
* Have a diagnosis of LS with a confirmed pathogenic variant in MLH1, MSH2, MSH6, PMS2 or EPCAM genes
* Aged 20 – 75 years
* Have an upcoming standard of care (SOC) colonoscopy appointment in line with standard LS surveillance guidelines (NCCN)
* Willing to sign informed consent, collect stools samples and complete surveys
Exclusion Criteria
* Individuals who have not proceeded with genetic testing and therefore are not known to have LS, despite family history and/or criteria for testing
* Individuals who have previously undergone a subtotal or total colectomy
* Newly diagnosed Lynch Syndrome patients < 20 years old with a pathogenic variant in MLH1, MSH2 or EPCAM, MSH6 or PMS2
* Individuals who are pregnant
* Individuals with inflammatory bowel disease or active malignancy
* Individuals not willing or able to sign informed consent
Additional locations may be listed on ClinicalTrials.gov for NCT06898996.
