Fitting Non-Invasive Tests in Lynch Syndrome Surveillance: A Prospective Clinical Study

Inclusion Criteria

• * Have a diagnosis of LS with a confirmed pathogenic variant in MLH1, MSH2, MSH6, PMS2 or EPCAM genes * Aged 20 – 75 years * Have an upcoming standard of care (SOC) colonoscopy appointment in line with standard LS surveillance guidelines (NCCN) * Willing to sign informed consent, collect stools samples and complete surveys

Exclusion Criteria

• * Individuals who have not proceeded with genetic testing and therefore are not known to have LS, despite family history and/or criteria for testing * Individuals who have previously undergone a subtotal or total colectomy * Newly diagnosed Lynch Syndrome patients < 20 years old with a pathogenic variant in MLH1, MSH2 or EPCAM, MSH6 or PMS2 * Individuals who are pregnant * Individuals with inflammatory bowel disease or active malignancy * Individuals not willing or able to sign informed consent