Long-Term Follow-Up of Medulloblastoma Survivors that Received Craniospinal Irradiation

PRIMARY OBJECTIVES:

I. To describe and compare the long-term health outcomes among medulloblastoma survivors treated with radiation therapy on or according to the SJMB12 protocol with varying craniospinal doses, chemotherapy regimens, and radiation modalities:

Ia. To analyze regional differences in brain activity using fMRI among medulloblastoma survivors treated with different craniospinal doses, chemotherapy regimens and radiation modalities;

Ib. To investigate the long-term impact of posterior fossa syndrome (defined dichotomously and on a continuum of severity) among medulloblastoma survivors including neurological effects, differences in brain activity (fMRI), cognitive effects, speech/language/swallowing outcomes, motor performance, health-related quality of life, social and adaptive functioning;

Ic. To assess health-related quality of life (HRQOL) among medulloblastoma survivors treated with different craniospinal doses, chemotherapy regimens, and radiation modalities;

Id. To map changes in the working memory structural connectome among medulloblastoma survivors treated with varying craniospinal doses, chemotherapy regimens, and radiation modalities;

Ie. To explore the association of social drivers of health (SDOH) with health outcomes among medulloblastoma survivors treated with different craniospinal doses, chemotherapy regimens, and radiation modalities;

If. To evaluate and compare the neurologic effects, complications, surgical injury, and second neoplasms among medulloblastoma survivors treated with varying craniospinal doses, chemotherapy regimens, and radiation modalities;

Ig. To examine and compare endocrinologic effects and complications, including fertility, among medulloblastoma survivors treated with different craniospinal doses, chemotherapy regimens, and radiation modalities;

Ih. To characterize and compare cognitive effects among medulloblastoma survivors treated with varying craniospinal doses, chemotherapy regimens, and radiation modalities;

Ij. To evaluate and compare physiologic effects and complications (cardiorespiratory, musculoskeletal) among medulloblastoma survivors treated with different craniospinal doses, chemotherapy regimens, and radiation modalities.

OUTLINE: This is an observational study. Patients are assigned to 1 of 2 groups.

COHORT I (CSIMEMPHIS): Patients complete questionnaires, undergo functional magnetic resonance imaging (MRI), dual x-ray absorptiometry (DEXA), neurocognitive testing, scale for the assessment and rating of ataxia (SARA), physical activity and heart rate variability, sleep test, thyroid ultrasound, bone age radiograph, and blood sample collection on study. Patients' medical records are also reviewed.

COHORT II ( BRAINatomy2): Patients complete questionnaires, undergo functional MRI, DEXA, neurocognitive testing, SARA, physical activity and heart rate variability, sleep test, thyroid ultrasound, bone age radiograph, and blood sample collection on study. Patients may undergo an additional functional MRI on study. Patients' medical records are also reviewed.