Circulating Tumor DNA Guided Treatment with Elacestrant in Stage IIB or III Hormone Receptor Positive HER2 Negative Breast Cancer, CATE Trial

Inclusion Criteria

• SCREENING: Adults aged 18 years and older
• SCREENING: Previous diagnosis of anatomic stage IIB or anatomic stage III histopathologically or cytologically confirmed ER+, HER2-, breast cancer per local laboratory as per American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines. In the context of this trial, ER status will be considered positive if > 10% of tumor cells demonstrate positive nuclear staining by immunohistochemistry, with or without progesterone receptor positivity. Patients with progesterone receptor (PR) positive but ER-negative are not eligible
• SCREENING: Participants must have been diagnosed with ER+HER2- breast cancer at least five years ago and no more than 15 years ago and must have completed adjuvant endocrine therapy
• SCREENING: Participants must be off endocrine therapy for at least six months prior to screening
• TREATMENT: ctDNA positivity by NEXT Personal assay
• TREATMENT: No evidence of metastatic disease on staging scans * If imaging, after review with a radiologist, is low probability for metastatic disease, patients may proceed with enrollment. Patients with suspicious but inconclusive imaging results should undergo a diagnostic biopsy; if biopsy is negative patients are eligible for enrollment. Patients with positive imaging that is conclusive of metastatic disease, or biopsy proven metastatic disease, are not eligible
• TREATMENT: At the time of informed consent signature for treatment, participants may be either postmenopausal, premenopausal, or perimenopausal * Postmenopausal status is defined by: ** Age ≥ 60 ** Age < 60 and amenorrhea for 12 or more months (without an alternative cause) and follicle-stimulating hormone (FSH) and estradiol level within postmenopausal range per local laboratory reference ** Documentation of bilateral oophorectomy, at least one month before first dose of trial therapy * Premenopausal and perimenopausal participants must be willing to concurrently receive an luteinizing hormone-releasing hormone (LHRH) agonist, and the LHRH agonist must be initiated at least three to four weeks before the start of elacestrant and are planning to continue LHRH agonist treatment during treatment with elacestrant. This is based on the current Food and Drug Administration (FDA) approval of elacestrant in the metastatic setting which is limited to postmenopausal participants * Premenopausal or perimenopausal participants must be willing to use a highly effective method of contraception for the duration of trial treatment and for 120 days after the last dose of elacestrant OR if using barrier method of contraception must be willing to use a second form of contraception like occlusive cap with spermicidal foam/gel/film/cream/suppository ** Highly effective methods of contraception are non-hormonal (cooper) intrauterine device (IUD), surgical sterilization (bilateral tubal occlusion/ligation, partner who has had a vasectomy), and sexual abstinence
• TREATMENT: Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• TREATMENT: Absolute neutrophil count (ANC) > 1.0 x 10^9/L
• TREATMENT: Platelets > 100 x 10^9/L
• TREATMENT: Hemoglobin > 8.0 g/dL
• TREATMENT: Potassium, sodium, calcium, and magnesium Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0 grade < 1
• TREATMENT: Cockcroft-Gault based creatinine clearance > 50 mL/min
• TREATMENT: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3 x upper limit of normal (ULN)
• TREATMENT: Total serum bilirubin < 1.5 x ULN
• TREATMENT: Hypercholesterolemia and hypertriglyceridemia CTCAE v 5.0 grade < 1

Exclusion Criteria

• SCREENING: Known current metastatic disease
• SCREENING: Known contraindication to receiving elacestrant as per FDA package insert
• SCREENING: Current treatment with endocrine therapy
• SCREENING: Prior treatment with elacestrant or other investigational SERDs
• SCREENING: Current or past invasive cancer other than breast cancer, except: * Adequately treated basal or squamous cell carcinoma of the skin * Cancer survivors of previously diagnosed invasive cancer who were treated with curative intent and have no evidence of disease recurrence for five years or more and are considered low risk for future recurrence by the treating physician
• SCREENING: Patients in the screening phase, or in the randomized trial (treatment phase), cannot start receiving therapy on another therapeutic clinical trial
• SCREENING: Current use of strong and moderate CYP3A4 inducers/inhibitors or other prohibited concomitant medication unless an acceptable substitute is available, and the prohibited medication is discontinued at least five half-lives prior to initiation of elacestrant
• SCREENING: Participants who are pregnant
• TREATMENT: Any concurrent severe and uncontrolled medical condition that would, in the sponsor-investigator’s opinion, cause unacceptable safety risks or compromise compliance with the protocol including but not limited to:
• TREATMENT: Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral medication (uncontrolled Crohn’s disease or ulcerative colitis, uncontrolled chronic nausea, vomiting, diarrhea, malabsorption, or small bowel resection)
• TREATMENT: Females who are pregnant or breastfeeding
• TREATMENT: Moderate to severe liver impairment (Child-Pugh class B and C)
• TREATMENT: Hypercholesterolemia or hypertriglyceridemia > CTCAE v 5.0 grade 1
• TREATMENT: Participants who are currently or are planning lactation during elacestrant treatment. Lactation during and at least one week following the last dose of elacestrant is not allowed