Local Antibiotic Delivery using the Stimulan Rapid Cure Device for the Prevention of Infection after Breast Reconstruction with Tissue Expanders
This phase IV trial studies how well local antibody delivery using the Stimulan Rapid Cure device works in preventing infections after breast reconstruction surgery with tissue expanders (TEs) among women with breast cancer or who have genes that increase the risk of breast cancer. Usual care includes antibiotics given as an intravenous infusion into a vein in the arm at the time of surgery and by mouth after surgery. Stimulan Rapid Cure is a medical device made from a type of calcium that is safely absorbed by the body. During surgery, it is mixed with antibiotics such as vancomycin and gentamicin to form a paste. The paste is formed into small beads, and the beads are placed in areas at risk of infection. Once inside the body, they slowly dissolve over several weeks, releasing antibiotics directly to the area where they are needed most. Because they dissolve on their own, no second surgery is required to remove them. This may help reduce the chance of infection and support healing. Stimulan Rapid Cure may help decrease risk of infection after tissue expander placement.