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TLN-372 in Advanced KRAS Mutant Solid Tumors
Trial Status: active
The primary purpose of this study is to evaluate the safety, pharmacokinetics, and
anti-tumor activity of TLN-372 as a single agent and in combination with other anti-tumor
agents, in patients with advanced KRAS mutant solid tumors
Inclusion Criteria
Patients must have measurable disease at study entry.
Patients must have locally advanced or metastatic KRAS mutant solid tumors.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
Adequate organ function.
Exclusion Criteria
Patients must not have active brain metastases.
Patients must not have current or past history of central nervous system (CNS) involvement.
Patients must not have major surgery or severe trauma within 4 weeks prior to the start of the study.
Patients must not have any condition, including significant acute or chronic medical illness, active or uncontrolled infection, or the presence of laboratory abnormalities, that places patients at unacceptable risk of participating in this study.
Patients must not have clinically significant cardiovascular disease.
Pregnant or lactating.
Conditions that could affect drug absorption.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT07204340.
