Multiparametric Ultrasound for the Imaging of Cancerous and Non-cancerous Tissue in the Pancreas and Thyroid

Inclusion Criteria

• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer. Participants enrolled into the Memorial Sloan Kettering Cancer Center Pancreatic Registry protocol (Institutional Review Board [IRB] #: 02-102) will be eligible for this study. Specifically, related individuals without pancreatic cancer who are at-risk for developing pancreatic cancer and meet all of the following criteria (family health history will be self-reported)
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: 10 years younger than the earliest pancreatic cancer diagnosis in the family
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: Be at least 50 years old
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: Be at least 40 years old if diagnosed with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM) syndrome (CDKN2A/p16) or hereditary pancreatitis (PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate hereditary pancreatitis genes)
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: Be at least 35 years old if diagnosed with Peutz Jeghers syndrome (STK11 aka LKB1)
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: Not pregnant and not nursing
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: Relatives at least 21 years old with other high-risk clinical criteria that warrants pancreatic cancer surveillance or follow-up as determined by the project leader (Dr. Vineet Rolston)
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: Must agree to be contacted for follow-up
• PROJECT 1-FEASIBILITY OF mpEUS IMAGING OF PATIENTS AT HIGH-RISK FOR PANCREATIC CANCER: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer: Must satisfy at least one of the following 4 criteria: * Have at least two affected relatives who are a first-degree relative to each other, of whom at least one is a first degree relative to the individual OR have at least two affected first-degree relatives on the same side of the family * Have at least one first- or second-degree affected relative and have germline genetic test results that confirm a likely pathogenic or pathogenic variant in at least one of the following genes: ** Adenomatosis polyposis coli (APC) (Familial Adenomatous Polyposis [FAP] and Attenuated FAP syndrome) ** BRCA1 (Hereditary Breast and Ovarian Cancer Symptoms) ** MLH1, MSH2, MSH6, PMS2, or EPCAM (Lynch Syndrome) ** PALB2 ** TP53 (Li-Fraumeni Syndrome) ** Other established pancreatic cancer predisposition gene per project leader’s discretion * Have germline genetic test results that confirm a likely pathogenic or pathogenic variant in one or more of the following genes: ** CDKN2A/p16 (Familial Atypical Multiple Mole Melanoma Syndrome [FAMMM]) ** STK11 aka LKB1 (Peutz-Jeghers Syndrome) ** PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate hereditary pancreatitis genes per project leader’s discretion ** ATM (ataxia telangiectasia mutated) ** BRCA 2 (Hereditary Breast and Ovarian Cancer Symptoms) * Relatives at least 21 years old with other high-risk clinical criteria that warrants pancreatic cancer surveillance or follow-up as determined the project leader (Dr. Vineet Rolston)
• PROJECT 2-mpEUS OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA: Patient Group: those with pancreatic cancer having endoscopic ultrasound-guided biopsies: Patients with pancreatic ductal adenocarcinoma
• PROJECT 2-mpEUS OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA: Patient Group: those with pancreatic cancer having endoscopic ultrasound-guided biopsies: Are undergoing endoscopic ultrasound-guided tissue core biopsy as part of their standard of care
• PROJECT 2-mpEUS OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA: Patient Group: those with pancreatic cancer having endoscopic ultrasound-guided biopsies: Not pregnant and not nursing
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Patient Group: those with a thyroid nodule that will be biopsied whether they have known cancer or not: Are undergoing ultrasound-guided thyroid biopsy as part of their standard of care
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Patient Group: those with a thyroid nodule that will be biopsied whether they have known cancer or not: Not pregnant and not nursing
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Healthy Volunteers: No known cancer diagnosis or thyroid nodules
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Healthy Volunteers: Age ≥ 18
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Healthy Volunteers: Able to understand and give informed consent
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Healthy Volunteers: Not pregnant and not nursing

Exclusion Criteria

• PROJECT 2-mpEUS OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA: Patient Group: those with pancreatic cancer having endoscopic ultrasound-guided biopsies: Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
• PROJECT 2-mpEUS OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA: Patient Group: those with pancreatic cancer having endoscopic ultrasound-guided biopsies: Under 18 years of age
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Patient Group: those with a thyroid nodule that will be biopsied whether they have known cancer or not: Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
• PROJECT 3-THYROID NODULE ASSESSMENT WITH mpUS IMAGING: Patient Group: those with a thyroid nodule that will be biopsied whether they have known cancer or not: Under 18 years of age