[18F]4FN PET/CT Imaging for Assessing Patients with Chronic Graft versus Host Disease
This phase II trial tests how well using [18F]4FN PET/CT imaging works for assessing patients with chronic graft versus host disease (GVHD). A PET scan is a procedure in which a small amount of radioactive tracer is injected into a vein, and a scanner is used to make detailed, computerized pictures of areas inside the body where the radiotracer is taken up. Because certain types of cells cells often take up more radioactive tracer than normal cells, the pictures can be used to find these cells in the body. CT scan is a procedure that uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-dimensional (3-D) views of tissues and organs. Combining a PET scan with a CT scan can help make the image easier to interpret. PET/CT scans are hybrid scanners that combine both modalities into a single scan during the same examination. [18F]4FN is a tracer that accumulates in normal tissue and areas where GVHD is present and is visible during imaging and may detect areas where GVHD is present or is starting to develop. Using [18F]4FN PET/CT imaging may work well for assessing patients with chronic GVHD.