Characterizing the Microvascular Environment of Bladder Cancer with Super-Resolution Ultrasound Localization Microscopy

Inclusion Criteria

• * Adults > 18 years * Histological evidence of urothelial cancer of the bladder for which radical cystectomy is recommended as per the treating physician (e.g., MIBC or high-risk NMIBC, such as high-grade T1 BCG refractory and worrisome histological variants)

Exclusion Criteria

• * Known or suspected hypersensitivity to sulfur hexafluoride lipid microsphere or its components, such as polyethylene glycol (PEG). * Pregnancy or breastfeeding * Decline to participate in the study * Subjects who had serious allergic reactions to COVID-19 vaccination. * Subjects with unstable conditions such as hospital in-patients, ICU patients, or high-risk cardiac diseases (unstable cardiopulmonary conditions, including acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, or serious ventricular arrhythmias).