This clinical trial develops and tests a culturally adapted educational intervention for increasing knowledge about and uptake of genetic counseling and testing among African American survivors of breast, prostate, or colorectal cancer. Genetic research has improved the understanding of how cancer develops and is useful for facilitating the identification of populations at high risk for developing certain cancers. Hereditary cancer syndromes are estimated to account for 5-15% of breast, prostate, and colorectal cancers and the identification of variants in genes known to cause these cancers has enhanced efforts to improve early detection and prevention of them. However, current genomic research lacks representation of African American patients, and the current understanding of genetic risk factors may have limited applicability and benefit to African Americans. A culturally-appropriate educational intervention that provides cost-effective and easy access to genetic counseling and testing information and that addresses specific and unique barriers to uptake of genetic testing may improve knowledge and uptake of genetic counseling and testing among African American cancer survivors.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT07436078.
Locations matching your search criteria
United States
Michigan
Detroit
Wayne State University/Karmanos Cancer InstituteStatus: Active
Contact: Felicity Harper
Phone: 313-576-8763
PRIMARY OBJECTIVES:
I. Guided by the Obesity-Related Behavioral Intervention Trials (ORBIT) model and in partnership with community stakeholders and clinical genetic professionals, adapt (Phase Ia) and refine (Phase Ib) a culturally relevant online educational genetic counseling (GC) intervention for at-risk African Americans.
II. Conduct a Phase IIa single-group proof-of-concept test of the effects of the educational intervention designed to increase the uptake of genetic counseling and testing (GCT) among at-risk African American survivors.
III. Collaborate with community stakeholders and clinical genetic professionals to translate study findings, develop a roadmap for dissemination to the community, and identify implementation barriers to prepare for a future Phase IIb randomized trial.
OUTLINE: Patients are assigned to 1 of 2 aims.
AIM 1: Patients view an educational video about genetic counseling and testing and participate in an interview to provide feedback on the intervention on study.
AIM 2: Patients view an educational video about genetic counseling and testing. Patients who indicate an interest in genetic testing after viewing the video may receive a referral to a genetic counseling service.
After completion of study intervention, patients from Aim 2 are followed up at 3 months.
Trial PhaseNo phase specified
Trial Typescreening
Lead OrganizationWayne State University/Karmanos Cancer Institute
Principal InvestigatorFelicity Harper