Vitamin E and Selenium in Preventing Cataracts and Age-Related Macular Degeneration

Inclusion Criteria

• The potential S0000B (SEE) participant must be a SELECT participant at the time of registration to SEE; participants may be registered to SEE at any time after SELECT randomization; participants are registered only after they report an eye event of interest
• The potential participant must report a diagnosis of age-related macular degeneration (AMD) at baseline (contact 010) or at follow-up, or a diagnosis of cataract or a cataract extraction at follow-up (effective November 1, 2009 accrual of new participants based solely on a diagnosis of cataract or a cataract extraction at follow-up is closed) * The potential participant must report a diagnosis of age-related macular degeneration (AMD) at baseline (contact 010) or at follow-up, or a diagnosis of cataract or a cataract extraction at follow-up (effective November 1, 2009 accrual of new participants based solely on a diagnosis of cataract or a cataract extraction at follow-up is closed) * A participant who reported a previous diagnosis of cataract at baseline (contact 010), then reports a cataract event (another cataract diagnosis or a cataract extraction) at follow-up, is not eligible * A participant who reported a previous diagnosis of cataract at baseline (contact 010), then reports a diagnosis of AMD at follow-up is eligible
• Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines before SEE procedures are initiated; participants must have signed an applicable medical records release form and it must have been sent to Dr. William Christen at the SELECT Eye Endpoints (SEE) Center in Boston, MA by FAX (FAX #: 617/278-2030) immediately after registration to SEE
• At the time of participant registration, the treating institution's name and identification (ID) number must be provided to the Statistical Center in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered into the database