A Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Cancers

Inclusion Criteria

• Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
• Must have recovered from all side effects of their most recent systemic or local treatment
• Adequate hematological, renal and liver function For solid tumors only:
• Histologically confirmed cancers (excluding melanoma and papillary thyroid cancer) with a BRAF V600 mutation and that are resistant to standard therapy or for which standard or curative therapy does not exist
• Measurable disease according to Response Evaluation Criteria In Solid Tumors (RECIST) For multiple myeloma only:
• Confirmed diagnosis of multiple myeloma with a BRAF V600 mutation
• Must have received at least one prior systemic therapy for the treatment of multiple myeloma
• Treated with local radiotherapy
• Must have relapsed and/or refractory multiple myeloma with measurable disease

Exclusion Criteria

• Melanoma, papillary thyroid cancer or hematological malignancies (with the exception of multiple myeloma)
• Uncontrolled concurrent malignancy
• Multiple myeloma: solitary bone or solitary extramedullary plasmacytoma as the only evidence of plasma cell dyscrasia
• Active or untreated central nervous system (CNS) metastases
• History of or known carcinomatous meningitis
• Concurrent administration of any anti-cancer therapies other than those administered in this study
• Other severe, acute, or chronic medical or psychiatric condition or laboratory abnormality that would, in the investigator's opinion, contraindicate participation in this study