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Nivolumab with or without Varlilumab in Treating Patients with Relapsed or Refractory Aggressive B-cell Lymphomas

Trial Status: closed to accrual and intervention

This phase II trial studies how well nivolumab with or without varlilumab works in treating patients with aggressive B-cell lymphomas that have come back (recurrent) or do not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as varlilumab and nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.