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Nanotechnology Characterization Lab Collaborators

All of NCL's programs (Assay Cascade, cCRADA, Technical Services) are open to researchers from any institution. Non-US organizations are also eligible.

Recent Collaborators

NaDeNo Nanoscience AS
NaDeNo Nanoscience is a recent spin-off company from SINTEF located in Norway. The company technology utilizes biodegradable poly(alkyl cyanoacrylate) (PACA) nanoparticles to encapsulate active substances for drug delivery, and this technology has been extensively studied, patented, and published at SINTEF over the last decade. Our lead candidate is cabazitaxel encapsulated in PACA nanoparticles, intended for local treatment of metastatic cancer in the peritoneum.

Nanokide Therapeutics
Nanokide Therapeutics is a biotechnology company focused on the development of novel antimetastatic solutions based on the combination of nanotechnology and microRNA and mRNA. Our nanosystem is a flexible, non-toxic and easy to produce formulation that, combined with microRNA and mRNA sequences, offers a perfect platform for anticancer drugs development.

VerImmune is a biotechnology company developing a first-in-class cancer therapy known as Anti-tumor Immune Redirection (AIR). This strategy utilizes a proprietary virus-inspired particle (ViP) platform that redirects pre-existing pathogenic or childhood vaccine immune memory towards tumors. This unique mechanism of action allows differentiation within the competitive Immuno-Oncology market. Our strategy transforms the patient's tumor to become susceptible to their own pre-existing endogenous or childhood vaccine immunity. This approach has the potential to change treatment outcomes for many cancer patients who are ineligible for current immuno-therapeutic drugs or have experienced resistance from currently available treatments.


Yechezkel (Chezy) Barenholz, Hebrew University Hadassah Medical School
“NCL worked on two projects for my lab and one of the start-ups I founded, LipoCureRX LTD. In both projects, NCL studies provided invaluable characterization assistance for two liposomal products being developed at LipoCure. NCL provided extensive analysis of the physical and chemical properties of the formulations, including detailed studies on the stability and degradation products of the formulation, in vitro cytotoxicity studies in multiple cell lines, multiple in vitro immunotoxicity studies to build upon our knowledge of the formulation’s safety profile, extensive assistance in endotoxin testing, and in vitro and in vivo pharmacokinetic studies. The expert analysis of these data helped to solidify our regulatory approach for these products, and we are currently in pre-IND discussions with the Food and Drug Administration (FDA). Additionally, the reports we received from NCL helped us to get an approval for the first-in-man study we performed in Israel.”

Matthieu Germain, Nanobiotix
"The NCL Assay Cascade was very useful to Nanobiotix for the development of one of our intravenously administered nanomedicine products. NCL's collaborative approach, from application through completion, was instrumental to our efforts. NCL adapted their characterization process to fit the needs of our project, tailored smart protocols to answer our questions in a timely manner, and provided meaningful results and suggestions throughout. Given this experience, we highly recommend application to the NCL Assay Cascade for companies aiming to accelerate product development.”

Andrew Brenner M.D., Ph.D., University of Texas Health Science Center
“The NCL has been pivotal for our group in the clinical translation of Rhenium Nanoliposomes and bringing this technology forward for our patients. As part of the pre-IND process, the Food and Drug Administration requested validation of our manufacturing techniques and additional drug characterization. This work was undertaken by the NCL, provided as part of the CMC section of our IND, and resulted in a successful IND application. Rhenium nanoliposomes are now completing phase 1 clinical trial, with phase 2 planned to begin within the year. We are extremely grateful for the expertise provided by the NCL.”

Jun Li, co-founder and CSO, ZY Therapeutics, Inc.
“ZY Therapeutics’ collaboration with NCL has enabled us to successfully advance ZY-010-PNP from discovery-phase toward a pending IND filing. In addition to the NCL team’s broad expertise in nanotechnology, open and concrete communications between NCL and ZY have proven critical to our progress. The NCL team’s input has helped us resolve several key technical issues, including an effective method to control endotoxin levels in ZY’s polymer which optimized our CMC process to meet standards for injectable formulations. Increased understanding of our formulation’s release kinetics, performed via NCL’s stable isotope tracer ultrafiltration assay, solidified our development strategy with this drug candidate. Most importantly, NCL shared with us their passion in finding improved therapy for cancer patients.

ZY technical team’s collaboration with NCL on the development of ZY-010-PNP has significantly reduced our cost and increased the development speed for this promising therapy. Without NCL input, we might still be struggling with many issues associated with natural complexity with nano-formulation.”

Andre Nel, Distinguished Professor of Medicine, University of California, Los Angeles
“NCL provided top quality characterization and evaluation of a nanocarrier intended for chemotherapy delivery in pancreas and colon cancer. The characterization was well planned, executed and we received comprehensive and detailed feedback that was extremely valuable in improving the safety and performance characteristics of our carrier. The NCL scientists indeed showed in-depth understanding of how to evaluate the characteristics and operational features of nano-enabled drug delivery systems, in vitro and in vivo. The interaction with the staff was pleasant and it was a real pleasure collaborating with NCL. NCL clearly constitutes one of the top places in the world to have nanomaterials characterized for therapeutic use.”

Jon Lovell, Associate Professor, University at Buffalo
"Working with the NCL was a valuable and educational experience. Their experienced and professional team characterized our formulation using numerous assays that cover a range of analytical testing parameters, many of which are critical but would not have occurred to me. Overall, the NCL greatly advanced our product development and we have subsequently been able to have a pre-IND meeting with the FDA.”

Academic Collaborators

  • Samuel Achilefu
    Washington University
  • Raag Airan
    Stanford University
  • Massoud Akhtari
    University of California, Los Angeles
  • Mansoor Amiji
    Northeastern University
  • Daniel Anderson
    Massachusetts Institute of Technology
  • Yechezkel (Chezy) Barenholz
    Hebrew University
  • Angela Belcher
    Massachusetts Institute of Technology
  • Peter Bonitatibus
    Rensselaer Polytechnic Institute
  • Andrew Brenner
    University of Texas, Health Science Center
  • Esther Chang
    Georgetown University
  • Ashutosh Chilkoti
    Duke University
  • James Connor
    Penn State Cancer Institute
  • Antonio Costa
    University of Connecticut
  • Heike Daldrup-Link
    Stanford University
  • Katherine Ferrara
    University of California, Davis
  • Mauro Ferrari
    Houston Methodist Research Institute
  • Darin Furgeson
    University of Wisconsin–Madison
  • Alberto Gabizon
    Shaare Zedek Medical Center
  • Sanjiv (Sam) Gambhir
    Stanford University
  • William Gmeiner
    Wake Forest School of Medicine
  • Jordan Green
    Johns Hopkins University
  • Peixuan Guo
    Ohio State University
  • P. Jack Hoopes
    Dartmouth College
  • Jeremiah Johnson
    Massachusetts Institute of Technology
  • Alexander Kabanov
    University of North Carolina
  • Efstathios Karathanasis
    Case Western Reserve University
  • Kattesh Katti
    University of Missouri
  • Mark Kester
    Penn State College of Medicine
  • Joachim Kohn
    Rutgers University 
  • Jindrich Kopecek
    University of Utah
  • Raoul Kopelman
    University of Michigan
  • Young Jik Kwon
    University of California, Irvine
  • Robert Lee
    Ohio State University
  • Chun Li
    University of Texas MD Anderson Cancer Center
  • Julia Ljubimova
    Cedars-Sinai Medical Center
  • Jonathan Lovell
    University at Buffalo
  • Zheng-Rong Lu
    Case Western Reserve University
  • Anirban Maitra
    Johns Hopkins University
  • John McDonald
    Georgia Tech Research Corporation
  • Andrew Miller
    Imperial College London
  • James Moon
    University of Michigan
  • Russ Mumper
    University of North Carolina
  • Yusuke Nakamura
    University of Chicago
  • Andre Nel and Huan Meng
    University of California, Los Angeles
  • Shuming Nie
    Emory University
  • Chong-xian Pan
    University of California, Davis
  • Martin Philbert
    University of Michigan
  • Robert Prud'homme
    Princeton University
  • Lenny Rome
    University of California, Los Angeles
  • Erkki Ruoslahti
    University of California, Santa Barbara
  • Aliasger Salem
    University of Iowa
  • Devanand Sarkar
    Virginia Commonwealth University
  • Janet Sawicki
    Lankenau Institute for Medical Research
  • Anna Schwendeman
    University of Michigan
  • Eric Simanek
    Texas A&M University
  • Anil Sood
    University of Texas MD Anderson Cancer Center
  • Matthias Stephan
    Fred Hutchinson Cancer Research Center
  • C. Shad Thaxton
    Northwestern University
  • Vladimir Torchilin
    Northeastern University
  • Ed Turos
    University of South Florida
  • Alex Wei
    Purdue University
  • Lily Yang
    Emory University
  • John Yu
    Cedars-Sinai Medical Center
  • William Zamboni
    University of North Carolina
  • Miqin Zhang
    University of Washington

Corporate Collaborators

  • Aadi Bioscience
  • Alnis Biosciences
  • Altus Formulation
  • Amgen
  • Arrowhead Pharmaceuticals
  • AstraZeneca
  • Avidea Technologies
  • Avidimer Therapeutics
  • Azaya Therapeutics
  • Bexion Pharmaceuticals
  • BIND Therapeutics
  • Bio-Synectics
  • BW Therapeutics
  • Carigent Therapeutics
  • Celator Pharmaceuticals
  • City of Hope
  • Cnano Medicine
  • Co-D Therapeutics
  • Concarlo Holdings
  • Curadigm
  • Cureport
  • CuriRx
  • CytImmune Sciences
  • Dendritic NanoTechnologies
  • Egen
  • Ensysce Biosciences
  • Eunoia Biotech
  • Evident Technologies
  • GE Global Research
  • Haima Therapeutics
  • Intezyne Technologies
  • January Therapeutics
  • Kereos
  • LaboPharm
  • LipoCure
  • Luna Innovations
  • Merck KGaA
  • Merrimack Pharmaceuticals
  • MonTa Biosciences
  • NaDeNo Nanosciences
  • Nanobiotix
  • NanoHybrids
  • Nanokide Therapeutics
  • Nanology Labs
  • Nanoprobes
  • NanoScan Imaging
  • Nanospectra Biosciences
  • Nanovalent Pharmaceuticals
  • Nemucore Medical Innovations
  • Oncolmmune
  • Ontario Institute for Cancer Research
  • Panacea Biotec
  • Parabon NanoLabs
  • PDS Biotechnology
  • PeptiMed
  • Pfizer
  • ProNAi Therapeutics
  • Proteogenomics Research Institute
  • Qualiber
  • Rexahn Pharmaceuticals
  • Salvacion USA
  • Seva Therapeutics
  • SignaBlok
  • Signpath Pharma
  • Siva Therapeutics
  • SN BioScience
  • SunTec Medical
  • SynerGene Therapeutics
  • Tego Biosciences
  • Tyndall Formulation Services
  • VerImmune
  • Westwood Bioscience
  • ZY Therapeutics

Government Collaborators

  • FDA’s Center for Biologics Evaluation and Research
  • FDA’s Center for Devices and Radiological Health
  • FDA’s Center for Drug Evaluation and Research
  • FDA’s Center for Food Safety and Applied Nutrition
  • FDA’s National Center for Toxicological Research
  • FDA’s Office of Generic Drugs
  • NCI’s Center for Cancer Research
  • National Institute of Environmental Health Sciences
  • United States Army Center for Environmental Health Research
  • United States Army Medical Research Institute for Infectious Diseases
  • Updated:

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