This phase II trial studies computed tomography (CT) compared to magnetic resonance imaging (MRI) in detecting lesions or area of abnormal tissues in patients scheduled for breast biopsy. Diagnostic procedures, such as breast CT, may help find and diagnose breast cancer and find out how far the disease has spread.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT00584233.
PRIMARY OBJECTIVE:
I. To evaluate the efficacy of breast computed tomography (CT) for breast cancer detection.
II. Develop scatter correction and image processing methods to improve Hounsfield Unit (HU) accuracy.
III. Optimize non-contrast breast (b)CT imaging for microcalcification detection.
IV. Imaging women using breast CT and contrast enhanced (CE)- magnetic resonance imaging (MRI).
OUTLINE:
Patients undergo breast CT, then receive an iodinated contrast agent intravenously (IV) over 25 seconds and undergo breast CT again. Patients undergo breast MRI, then receive gadodiamide IV and undergo breast MRI again. Patients who are unable to undergo MRI may undergo CT only.
After completion of the study intervention, patients are followed up between 2-3 months.
Lead OrganizationUniversity of California Davis Comprehensive Cancer Center
Principal InvestigatorAndrew Hernandez
