Levonorgestrel Intrauterine Device in Preventing Ovarian Cancer in Patients Undergoing Surgical Removal of the Fallopian Tubes and Ovaries

Inclusion Criteria

• Women seeking an RRSO or RRS at MSK, including breast cancer 1 (BRCA 1)/breast cancer 2 (BRCA2) mutation carriers and women with a strong family history of breast and or/ovarian cancer
• Women who will be scheduled to undergo an RRSO or RRS
• Women who will have at least one fallopian tube removed for risk-reducing reasons (with or without removal of ovar[ries])
• Women who are willing to have a Mirena IUD inserted at least 10 days prior to risk-reducing surgery or who already have the Mirena in place
• Women using non-hormonal forms of contraception *(Note: If a copper IUD is being used, the IUD must be removed prior to or at time of Mirena insertion)

Exclusion Criteria

• Any medical contradiction to use of a Mirena IUD, including: * Pregnancy (a pregnancy test is required prior to study entry) * Known uterine anomaly that distorts the shape of the uterine cavity * Acute pelvic inflammatory disease * Postpartum endometritis or endometrial infection * Known or suspected uterine or cervical neoplasia * Known history or suspected breast cancer or other progestin-sensitive cancer * Uterine bleeding of unknown etiology * Untreated acute cervicitis, vaginitis, or other lower genital tract infections * Acute liver disease or liver tumor (benign or malignant)
• Use of tamoxifen, raloxifene, or chemotherapy within the previous 6 months
• Positive pregnancy test
• Breastfeeding
• Use of a copper IUD if the patient is not willing to have it removed prior to surgery and replaced with a Mirena IUD