This research trial studies metabolic changes in blood samples from patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help doctors learn more about cancer and the development of drug resistance.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT02581917.
PRIMARY OBJECTIVE:
I. To determine the metabolic adaptations that occur following exposure to standard chemotherapeutic agents using peripheral blood mononuclear cells from acute myeloid leukemia (AML) patients.
OUTLINE:
Patients undergo collection of peripheral blood mononuclear cell (PBMC) samples for analysis via cell isolation, glycolytic flux and oxygen consumption assays, viability assays, western blot, and metabolite assays at baseline and 4, 8, 24, 48, and 72 hours after starting chemotherapy.
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationWake Forest University Health Sciences
Principal InvestigatorTimothy S. Pardee