Akt/ERK Inhibitor ONC201 in Treating Patients with Advanced Solid Tumors or Multiple Myeloma

Inclusion Criteria

• Solid tumor specific: * Patients must have a histologically/cytologically confirmed primary solid tumor * Radiographic or clinical evidence of advanced/metastatic disease that is resistant to standard therapy or for which no standard therapy is available; lesions may be measurable or non-measurable
• Multiple myeloma specific: * Confirmed evidence of disease progression from immediately prior multiple myeloma (MM) therapy or refractory to the immediately prior treatment * Measurable disease M protein component in serum (at least 0.5 g/dL) and/or urine (if present), (>=0.2 g excreted in a 24 hour collection sample) * Subjects with free light chain only disease are excluded
• All previous therapies for cancer, including radiotherapy, major surgery and investigational therapies must be discontinued for >= 14 days (>= 28 days for mitomycin C or nitrosoureas) before cycle 1 day 1 (C1D1), and all acute effects of any prior therapy must have resolved to baseline severity or grade =< 1 Common Terminology Criteria for Adverse Events (CTCAE version [v] 4.03), except alopecia or parameters defined in this eligibility list
• Eastern Cooperative Oncology Group (ECOG) performance status =< 1
• Absolute neutrophil count >= 1,000/mm^3 without growth factor use =< 7 days prior to C1D1
• Platelets >= 75,000/mm^3 without platelet transfusion =< 7 days prior to C1D1
• Hemoglobin >= 8.0 mg/dL without red blood cell transfusion =< 7 days prior to C1D1
• Total serum bilirubin =< 1.5 X upper limit of normal (ULN)
• Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2 X ULN; =< 5 X ULN if liver dysfunction is felt to be secondary to tumor burden
• Serum creatinine =< 1.5 X ULN (OR creatinine clearance >= 60 mL/min/1.73 m^2)
• Serum or urine pregnancy test (for females of childbearing potential) negative =< 7 days of registration
• Ability to understand and the willingness to sign a written informed consent document and comply with the study scheduled visits, treatment plans, laboratory tests and other procedures
• Female patients must be surgically sterile or be postmenopausal, or must agree to use effective contraception during the period of the trial and for at least 90 days after completion of treatment; male patients must be surgically sterile or must agree to use effective contraception during the period of the trial and for at least 90 days after completion of treatment; the decision of effective contraception will be based on the judgment of the principal investigator or a designated associate

Exclusion Criteria

• Patients with symptomatic brain metastases are excluded; patients with asymptomatic and treated central nervous system (CNS) metastases may participate in this trial; the patient must have completed any prior treatment for CNS metastases > 28 days prior to study entry, including radiotherapy or surgery; steroids for the treatment of brain metastasis are not permitted
• Active inflammatory gastrointestinal disease such as chronic diarrhea (unless related to underlying malignancy or prior related treatment) or history of abdominal fistula, gastrointestinal perforation, peptic ulcer disease, or intra-abdominal abscess within 6 months prior to study enrollment; gastroesophageal reflux disease under treatment with proton pump inhibitors is allowed
• Pregnancy or breast feeding
• Current active treatment in another clinical study
• Active bacterial, fungal or viral infection including hepatitis B (HBV), hepatitis C (HCV) , requiring treatment with intravenous (IV) antibiotic, IV anti-fungal, or anti-viral; (testing is not required for eligibility)
• Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness; (testing is not required for eligibility)
• Multiple myeloma specific: * Active or prior plasma cell leukemia (defined as either 20% of peripheral white blood cell [WBC] comprised of plasma/cluster of differentiation [CD]138+ cells or an absolute count of 2 x 10^9/L) * Solitary bone or solitary extramedullary plasmacytoma as the only evidence of plasma cell dyscrasia
• Subjects with serum calcium (corrected for albumin) >= 12 mg/dL
• Any of the following in the previous 6 months: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack or symptomatic pulmonary embolism
• Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, or in the judgment of the investigator would make the patient inappropriate for entry into the study