High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients with Pancreatic Cancer That Can Be Removed by Surgery

Inclusion Criteria

• The subject has a surgical indication for pancreatectomy (pancreaticoduodenectomy, distal pancreatectomy, total pancreatectomy) as determined by the treating physician/surgeon
• A diagnosis of pancreatic or other periampullary cancer is suspected preoperatively
• In the opinion of the surgeon, the subject has no medical contraindications to pancreatectomy
• Age ≥ 18 years of age
• The subject is willing to consent to randomization of extensive abdominal lavage-saline (EAL-S) vs. EAL- water (W) vs. no extensive lavage (standard of care [SOC])

Exclusion Criteria

• The subject does not have a surgical indication for pancreatectomy
• In the opinion of the surgeon, the subject has medical contraindications to pancreatectomy
• Age < 18 years of age
• The subject is not willing to consent to EAL-S lavage vs. EAL-W vs. no extensive lavage (SOC)
• Known benign or indolent disease (including benign pancreatic cystic tumors or pancreatic endocrine tumors) without possible risk of malignancy
• Other malignancy within five years, unless the probability of recurrence of the prior malignancy is < 5% as determined by the principal investigator based on available information; patient’s curatively treated for squamous and basal cell carcinoma of the skin or patients with a history of malignant tumor in the past that have been disease free for at least five years are also eligible for this study
• Evidence of metastatic disease preoperatively