This clinical trial studies genetic test results from patients or family members of patients who have suspected or known thyroid cancer or nodules to identify risk factors for inherited thyroid cancer. Genetic testing can help doctors to find changes in deoxyribonucleic acid (DNA) that can occur in normal cells and can be passed from parent to child. A better understanding of genetic changes that cause cancer can lead to improved cancer prevention, early detection, and treatment strategies.
Additional locations may be listed on ClinicalTrials.gov for NCT02747888.
Locations matching your search criteria
United States
Massachusetts
Boston
Dana-Farber Cancer InstituteStatus: Active
Contact: Junne Kamihara
Phone: 617-632-3044
Boston Children's HospitalStatus: Active
Contact: Junne Kamihara
Phone: 617-632-3044
PRIMARY OBJECTIVES:
I. To describe a cohort of individuals with childhood or suspected familial thyroid cancers/nodules.
II. To estimate the prevalence of suspected familial cancer predisposition among individuals with childhood thyroid cancer/nodules.
III. To identify genetic and other factors associated with familial thyroid cancer predisposition.
OUTLINE:
Participants provide information about medical and family history of cancer through medical chart review and questionnaires. Participants undergo specimen collection of saliva and/or blood for genetic testing including but not limited to targeted gene sequencing, whole exome, whole genome, or transcriptome sequencing. If available, samples of tissue from cancer(s) or pre-cancerous cells collected for clinical care purposes are also used for genetic testing. Participants receive test results from a genetic counselor and are referred to genetic counseling if clinically indicated.
Trial PhaseNo phase specified
Trial Typescreening
Lead OrganizationDana-Farber Harvard Cancer Center
Principal InvestigatorJunne Kamihara
