This pilot clinical trial studies how well functional magnetic resonance imaging (MRI) and diffusion imaging work in improving brain tumor resection planning in patients with brain tumors. Functional MRI and diffusion imaging may give doctors a better view of where brain tumors are located relative to important parts of the brain.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT01534104.
PRIMARY OBJECTIVES:
I. To compare standard versus (vs.) probabilistic tractography in localizing white matter tracts.
II. To evaluate standard and probabilistic diffusion tensor imaging (DTI) and diffusion spectrum imaging (DSI) tractography results with direct electrical stimulation during brain tumor surgery.
III. To evaluate the utility of advanced diffusion imaging in brain tumor patients for white matter tract localization. (Optional)
EXPLORATORY OBJECTIVE:
I. To evaluate the feasibility of updated functional MRI (fMRI) sequences. (Optional)
OUTLINE:
Patients undergo preoperative single-echo task-based fMRI and DTI. Patients may also undergo optional DSI, restriction spectrum imaging (RSI), and multi-echo task-based fMRI and/or resting-state fMRI.
Trial PhaseNo phase specified
Trial Typediagnostic
Lead OrganizationMemorial Sloan Kettering Cancer Center
Principal InvestigatorRobert J. Young
