Reduced Calorie Diet in Reducing Wound Complications in Patients with Soft Tissue Sarcomas Undergoing Surgery after Radiation Therapy

Inclusion Criteria

• Age ≥ 18 years
• Biopsy proven sarcoma located in the lower extremities
• Patient to be treated with radiation therapy for a primary lower extremity soft tissue sarcoma or recurrent tumor after surgery, followed by surgical resection
• Karnofsky score >= 60%
• Body mass index (BMI) >= 20 kg/m^2
• Protein levels within normal limits (lab results must be within 45 days prior enrollment)
• Normal kidney and liver function (lab results must be within 45 days prior enrollment)
• Normal blood counts (lab results must be within 45 days prior enrollment)
• Normal chemistries (lab results must be within 45 days prior enrollment)
• All blood levels will be assessed by the treating physician for protocol eligibility

Exclusion Criteria

• Current pregnancy and breast feeding
• Other cancers diagnosed within the last 5 years (in situ and/or invasive cancers)
• Diabetes mellitus
• Current metformin therapy
• Other conditions may exclude participants from the study (e.g. intractable nausea/emesis, allergic reaction to shake, patient decides not to have surgery, any medical condition that prevents patient from having surgery)