Trametinib in Treating Patients with Progressive Metastatic Castration-Resistant Prostate Cancer

Inclusion Criteria

• Willing and able to give informed consent
• Histologically confirmed prostate cancer (not exclusive of adenocarcinoma)
• mCRPC that has progressed on at least 1 therapy progression (defined as Prostate Cancer Working Group 2 [PCWG2] or at investigators’ discretion) approved for treatment of mCRPC, one of which must include abiraterone acetate and/or enzalutamide. Prior abiraterone acetate must be stopped at least 2 weeks prior to first dose of trametinib; enzalutamide must be discontinued at least 4 weeks prior to first dose of trametinib
• Metastatic tumor that has been biopsied
• Eastern Cooperative Oncology Group (ECOG) performance status of 0–2
• Willing to undergo biopsy of a metastatic lesion at the time of progression
• Patients must have ongoing therapy to maintain serum testosterone < 50 ng/dL
• Absolute neutrophil count > 1,500/uL during screening evaluation
• Platelet count > 100,000/uL during screening evaluation
• Hemoglobin > 8.0 g/dL during screening evaluation
• Total bilirubin within the reference range during screening evaluation
• Alanine aminotransferase (ALT) within the reference range during screening evaluation
• Aspartate aminotransferase (AST) within the reference range during screening evaluation
• Creatinine < (1.5 mg/dL) during screening evaluation (> 1.5 is allowed if estimated glomerular rate [EGFR] > 45 mL/min/1.73 m^2)
• International normalized ratio (INR) < 1.3 (or < 3 if on warfarin or other anticoagulants) during screening evaluation
• Left ventricular ejection fraction (LVEF) >= 45% as measured by echocardiogram during screening evaluation
• Electrocardiogram (EKG) without clinically significant abnormality

Exclusion Criteria

• A history of retinal vein occlusion (RVO) or risks factors for RVO
• A history of retinal pigment epithelial detachment (RPED) or risk factors for RPED
• Clinically significant abnormality on ophthalmologic examination during screening evaluation
• Clinically significant cardiovascular disease including: * LVEF < 45% measured by echocardiogram * History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty, or stenting within 6 months * Uncontrolled angina within 3 months * New York Heart Association (NYHA) class III or IV congestive heart failure * Clinically significant abnormality on EKG * History of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes) * Patients with intra-cardiac defibrillators or permanent pacemakers
• Presence of a comorbid disease or medical condition that would impair the ability of the patient to receive or comply with the study protocol
• History of interstitial lung disease or pneumonitis
• Use of any medication or herbal products that may have hormonal anti-prostate cancer activity and/or are known to modulate PSA levels (e.g., saw palmetto) or systemic corticosteroids greater than the equivalent of 10 mg of prednisone per day within 4 weeks of enrollment. (Note: this criterion excludes abiraterone acetate and enzalutamide. Prior abiraterone acetate must be stopped at least 2 weeks prior to first dose of trametinib; enzalutamide must be discontinued at least 4 weeks prior to first dose of trametinib.)
• Prior use of trametinib or other MAPK inhibitor in any context
• Known or suspected brain metastasis or active leptomeningeal disease or spinal cord compression
• Gastrointestinal disorder affecting absorption (e.g., gastrectomy, active peptic ulcer disease within last 3 months, inflammatory bowel disease)
• Any major surgery, extensive radiotherapy, chemotherapy with delayed toxicity, biologic therapy, or immunotherapy within 30 days of enrollment and/or daily or weekly chemotherapy without the potential for delayed toxicity within 14 days of enrollment
• Hospitalization within 30 days of enrollment for cancer related events
• History of another malignancy within the previous 5 years other than curatively treated non-melanoma skin cancer
• Use of an investigational agent within 4 weeks of enrollment
• Use of any medications known to affect the serum androgen level
• Any condition or reason that, in the opinion of the investigator, interferes with the ability of the patient to participate in the trial, which places the patient at undue risk, or complicates the interpretation of safety data