Intraoperative Electron Beam Radiotherapy Boost in Treating Patients with Stage I-III Breast Cancer Undergoing Surgery with Reconstruction

Inclusion Criteria

• Pathologically proven diagnosis of breast cancer
• The patient must be female
• The patient must be >= 18 years old
• Must have clinically anatomic stage I-III breast cancer prior to any breast cancer therapy
• Appropriate stage for protocol entry including no clinical evidence for distant metastases based upon the following minimum diagnostic workup: * History/physical examination, documentation of weight and Zubrod performance status 0-2 within 60 days prior to study entry
• Women of childbearing potential must be non-pregnant and non-lactating and willing to use highly effective form of contraception during radiation therapy
• Patients must provide study specific informed consent prior to study entry

Exclusion Criteria

• Clinical or pathological stage IV breast cancer
• Prior invasive non-breast malignancy (except non-melanomatous skin cancer, carcinoma in situ of the cervix) unless disease free for a minimum of 3 yrs prior to study entry
• Prior invasive or in-situ carcinoma of the breast (prior lobular breast carcinoma in situ [LCIS] is eligible)
• Two or more cancers not resectable through a single lumpectomy incision
• Ductal breast carcinoma in situ (DCIS) only
• Non-epithelial breast malignancies such as sarcoma/lymphoma
• Male breast cancer
• Paget’s disease of the nipple
• Prior radiotherapy to the breast or prior radiation to the region of the ipsilateral breast that would result in overlap of radiation fields
• Women of childbearing potential who are sexually active and not willing/able to use medically acceptable forms of contraception
• Active systemic lupus, erythematosus, or any history of scleroderma, dermatomyositis with active rash
• Medical, psychiatric or other condition that would prevent the patient from receiving the protocol therapy or providing informed consent