This randomized pilot clinical trial studies active breathing coordinator-mediated radiation therapy to see how well it works compared with VisionRT-based deep inspiratory breath hold radiation therapy works in treating patients with breast cancer. Active breathing coordinator-mediated radiation therapy and VisionRT-based deep inspiratory breath hold radiation therapy are used to help minimize heart and lung radiation dose during radiation treatment. VisionRT-based deep inspiratory breath hold radiation therapy may work better in treating patients with breast cancer.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT02694029.
PRIMARY OBJECTIVES:
I. To quantify residual motion during deep inspiratory breath-hold using active breathing coordinator-mediated radiation therapy (ABC) and VisionRT-based deep inspiratory breath hold radiation therapy (VisionRT) during left post-mastectomy chest wall radiotherapy.
II. To determine clinical and dosimetric impact of residual motion, on heart and lung dose.
SECONDARY OBJECTIVES:
I. To compare time of simulation and daily treatment for deep inspiratory breath-hold (DIBH) with both ABC and VisionRT.
II. To evaluate DIBH reproducibility of both ABC and VisionRT DIBH.
OUTLINE: Patients are randomized to 1 of 2 groups.
GROUP I: Patients undergo ABC once daily (QD) for 30-45 minutes for 14 fractions and then VisionRT QD for 30-45 minutes for 14 fractions.
GROUP II: Patients undergo VisionRT QD for 30-45 minutes for 14 fractions and then ABC QD for 30-45 minutes for 14 fractions.
Trial PhaseNo phase specified
Trial Typetreatment
Lead OrganizationUT Southwestern/Simmons Cancer Center-Dallas
Principal InvestigatorAsal Shoushtari Rahimi
