Effects of Aspirin on the Gut Microbiome in Healthy Volunteers

Inclusion Criteria

• Healthy adults who reside within the greater Twin Cities area
• Capable and willing to comply with the entire study protocol
• Able to give voluntary written informed consent

Exclusion Criteria

• Use of any aspirin-containing products or other non-steroidal anti-inflammatory drugs (NSAIDs) (>= 2 days per week on a regular basis)
• Known hypersensitivity to NSAIDs
• Any active cancer, history of gastrointestinal cancer, or chronic disease such as peptic ulcer, irritable bowel syndrome, inflammatory bowel disease, intestinal malabsorption syndrome or other gastrointestinal disorder
• History of any coagulation, bleeding, or blood disorders (e.g. anemia)
• History of stroke/transient ischemic attack
• Acute heart disease or history of heart attack, atrial fibrillation, or angina
• Diagnosis of dementia
• Use of antibiotics, antiplatelets (e.g. clopidogrel), or anticoagulants (e.g. warfarin) within the last 3 months
• Regular use of laxatives (e.g. Ex-lax, Dulcolax, Miralax) that may affect the microbiome >= 2 days a week
• Body mass index (BMI) greater than or equal to 40 or less than or equal to 17 kg/m^2 at screening visit
• Unexplained change in weight (> 4.5 kg) within the past 6 months
• Major changes in eating habits within the past 3 months
• Any serious or active medical or psychiatric illness which, in the opinion of the investigator, would interfere with subject treatment, assessment, or compliance